American diplomats typically discount religious belief and come across as rather condescending. So many are so steeped in their own secular world views that it is hard for them to conceive that others take their religion so seriously.
America ends up coming across to many countries as an arrogant bully refusing to take into account the belief systems and world views of others. Ignoring them rather than engaging in an exchange of ideas.
For instance, when religious leaders of a country like Iran say that they are waiting for the 12th Imam to return and that they want to usher in a new Islamic caliphate in preparation and utterly destroy Israel in the process.
American diplomats and political leaders find it hard to accept that anyone would actually believe that stuff and would rather think that it is all some kind of elaborate hoax used to control their own population or at best a negotiating ploy.
There is a total disconnect and what is clearly being said is not taken at face value but ends up being discounted or marginalized.
So American presidents like Obama and Biden continue to try and make treaties with those like Iran because they do not accept at face value their leader’s pronouncements that they intend to make A-bombs and utter destroy Israel.